Malignant germ cell tumors of the ovary
Objective: To evaluate the efficacy of adjuvant therapy for ovarian germ cell tumors. Methods: We reviewed records of women who had malignant germ cell tumors of the ovary from 1977–1997. Results: Seventy-two women had surgical resections of malignant ovarian germ cell tumors and most received adjuv...
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Published in | Obstetrics and gynecology (New York. 1953) Vol. 95; no. 1; pp. 128 - 133 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
2000
The American College of Obstetricians and Gynecologists Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Objective: To evaluate the efficacy of adjuvant therapy for ovarian germ cell tumors.
Methods: We reviewed records of women who had malignant germ cell tumors of the ovary from 1977–1997.
Results: Seventy-two women had surgical resections of malignant ovarian germ cell tumors and most received adjuvant therapy. Fifty-six women (78%) presented with stage I disease, and 16 (22%) had more advanced disease. Tumor subtypes included dysgerminoma (
n = 20), yolk sac tumor (
n = 8), immature teratoma (
n = 29) and mixed germ cell tumor (
n = 15). Surgical management of the 56 with stage I disease consisted of total abdominal hysterectomy, bilateral salpingo-oophorectomy, and extensive surgical staging in ten women, whereas a conservative surgical approach, consisting of unilateral adnexectomy with or without comprehensive surgical staging, was adopted in later years (
n = 46). Fifty-six women were treated with postoperative chemotherapy, predominantly platinum-based regimens. The 5-year actuarial survival rate was 93%. None of the 36 women who presented after 1984 have died of disease.
Conclusion: These data confirmed that platinum-based adjuvant treatments allow most women with ovarian germ cell malignancies to have conservative surgery without compromising survival. |
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ISSN: | 0029-7844 1873-233X |
DOI: | 10.1016/S0029-7844(99)00470-6 |