Granulocyte Colony Stimulating Factor (G‐CSF) and Olfactory Function—A Clinical Pilot Study

• Published in: Laryngoscope investigative otolaryngology Vol. 10; no. 3; pp. e70143 - n/a
• Main Authors: Hintschich, C. A., Resler, K., Brückner, C., Altundag, A., Trautmann, K., Hölig, K., Kroschinsky, F., Pieniak, M., Hummel, T.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2025; Wiley
• Subjects: Alzheimer's disease; Bone marrow; Chemotherapy; Disease; Granulocytes; Multiple myeloma; Neutropenia; olfaction; Otolaryngology; smell; Stem cells; Variance analysis; smell; stem cells; olfaction
• ISSN: 2378-8038; 2378-8038
• DOI: 10.1002/lio2.70143

ABSTRACT Background Although the olfactory epithelium, including its neuronal cell line, has inherent regenerative potential, therapeutic options remain limited. Promising effects of granulocyte colony stimulating factor (G‐CSF) on olfactory regeneration have been observed in both animal and human studies. In this study, we assessed olfaction before and after G‐CSF administration in myeloma patients who underwent autologous stem cell transplantation and in allogeneic stem cell donors. Methods A total of 40 subjects were included in this study (10 myeloma patients, 10 allogeneic stem cell donors, 20 controls who did not receive any G‐CSF). Olfactory function was psychophysically assessed using the threshold and extended identification domain of the Sniffin' Sticks test. Results After G‐CSF administration, threshold scores were slightly enhanced in both myeloma patients (8.9 ± 3.6 vs. 9.3 ± 3.3) and allogeneic stem cell donors (10.2 ± 3.5 vs. 11.8 ± 2.9). However, this effect was not statistically significant. For olfactory identification, no improvement was observed. Conclusion Even though being not statistically significant, the findings of this study align with previous evidence and underline the potential of G‐CSF on olfactory regeneration. However, additional studies, including carefully designed animal trials, are required to comprehensively evaluate this promising therapeutic option. Level of Evidence: 2. Promising effects of granulocyte colony stimulating factor (G‐CSF) on olfactory regeneration have been observed in both animal and human studies. Even though being not statistically significant, our study underlines the potential of G‐CSF on olfactory regeneration. However, carefully designed animal trials are required to comprehensively evaluate this promising therapeutic option.