Nicotine as an Antiepileptic Agent in ADNFLE: An N‐of‐One Study
Purpose: To test nicotine patch treatment for a patient with a defined mutation for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) whose seizures were refractory to standard antiepileptic therapy. Methods: Open and double‐blind trials of nicotine patches in an “n‐of‐one” study. The doub...
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Published in | Epilepsia (Copenhagen) Vol. 44; no. 9; pp. 1238 - 1240 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
350 Main Street , Malden , MA 02148 , U.S.A
Blackwell Science Inc
01.09.2003
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose: To test nicotine patch treatment for a patient with a defined mutation for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) whose seizures were refractory to standard antiepileptic therapy.
Methods: Open and double‐blind trials of nicotine patches in an “n‐of‐one” study. The double‐blind trial comprised periods during which either placebo or nicotine patches were each used for three periods of 2 weeks, randomized in a double‐blind manner.
Results: In an open study, nicotine patches reduced seizures from 1.65 ± 2.36 to 0.01 ± 0.0 seizures per day (p < 0.0001). In a double‐blinded placebo‐controlled phase, the average frequency of seizures on nicotine versus placebo was 0 ± 0 versus 0.56 ± 1.14 seizures per day (p < 0.0001).
Conclusions: Nicotine patches may be of benefit to some individuals with ADNFLE. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-News-5 ObjectType-Case Study-4 ObjectType-Feature-1 ObjectType-Report-3 |
ISSN: | 0013-9580 1528-1167 |
DOI: | 10.1046/j.1528-1157.2003.58102.x-i1 |