Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration

• Published in: European journal of oral sciences Vol. 119; no. 1; pp. 1 - 6
• Main Authors: Planello, Aline C., Campos, Maria I. G., Meloto, Carolina B., Secolin, Rodrigo, Rizatti-Barbosa, Célia M., Line, Sergio R. P., de Souza, Ana P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2011
• Subjects: Adult; Alleles; Case-Control Studies; Chi-Square Distribution; Computed tomography; Degeneration; Dentistry; Extracellular matrix; Female; Gelatinase B; Gene Frequency; Gene polymorphism; genetic polymorphism; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Magnetic Resonance Imaging; Male; Mandibular Condyle - diagnostic imaging; Mandibular Condyle - pathology; Matrix metalloproteinase; Matrix Metalloproteinase 1 - genetics; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 9 - genetics; Middle Aged; Pain; Polymerase chain reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Population studies; Promoter Regions, Genetic - genetics; Regression analysis; Restriction fragment length polymorphism; single nucleotide polymorphism; Stromelysin 1; Temporomandibular joint; Temporomandibular Joint Disorders - enzymology; Temporomandibular Joint Disorders - genetics; Tomography, X-Ray Computed
• ISSN: 0909-8836; 1600-0722
• DOI: 10.1111/j.1600-0722.2010.00803.x

Planello AC, Campos MIG, Meloto CB, Secolin R, Rizatti‐Barbosa CM, Line SRP, de Souza AP. Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration. 
 Eur J Oral Sci 2011; 119: 1–6. © 2011 Eur J Oral Sci Temporomandibular joint (TMJ) degeneration is a frequent cause of orofacial pain. Matrix metalloproteinases (MMPs) degrade extracellular matrix components and play an important role in TMJ degeneration. We investigated the frequency of the MMP1 1G/2G polymorphism (rs1799750), the MMP3 5A/6A polymorphism (rs3025058), and the MMP9 C/T polymorphism (rs3918242) in individuals with TMJ degeneration, in order to analyze the association of polymorphisms in these genes with TMJ degeneration. The population studied comprised 117 healthy controls and 115 individuals diagnosed with TMJ degeneration upon examination of magnetic resonance imaging (MRI) and computed tomography (CT) images. Genotypes were determined using PCR restriction fragment length polymorphism (RFLP). Logistic regression analyses revealed an association between the MMP1 2G/2G genotype and degeneration; in contrast, there was no association between either the MMP3 or the MMP9 genotype and degeneration. Our results may indicate a role for the MMP1 polymorphism in TMJ degeneration.