Clinical characteristics and risk factors for mortality in hematologic patients affected by COVID‐19

• Published in: Cancer Vol. 126; no. 23; pp. 5069 - 5076
• Main Authors: Cattaneo, Chiara, Daffini, Rosa, Pagani, Chiara, Salvetti, Massimo, Mancini, Valentina, Borlenghi, Erika, D’Adda, Mariella, Oberti, Margherita, Paini, Anna, De Ciuceis, Carolina, Barbullushi, Kordelia, Cancelli, Valeria, Belotti, Angelo, Re, Alessandro, Motta, Marina, Peli, Annalisa, Bianchetti, Nicola, Anastasia, Antonella, Dalceggio, Daniela, Roccaro, Aldo M., Tucci, Alessandra, Cairoli, Roberto, Muiesan, Maria Lorenza, Rossi, Giuseppe
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2020
• Subjects: Aged; Anemia; Betacoronavirus - isolation & purification; Blood diseases; Chronic infection; Chronic myeloid leukemia; Coronaviridae; coronavirus disease 2019 (COVID‐19); Coronavirus Infections - complications; Coronavirus Infections - transmission; Coronavirus Infections - virology; Coronaviruses; COVID-19; Diagnosis; Dyspnea; epidemiology; Female; Follow-Up Studies; Health risks; Health services; Hematologic Neoplasms - epidemiology; Hematologic Neoplasms - mortality; Hematologic Neoplasms - pathology; Hematologic Neoplasms - virology; hematologic patients; Hematological diseases; Humans; Infections; Italy - epidemiology; Leukemia; Male; Medical prognosis; Medical treatment; Mortality; Myeloid leukemia; Neoplasms; Oncology; outcome; Pandemics; Patients; Physicians; Pneumonia, Viral - complications; Pneumonia, Viral - transmission; Pneumonia, Viral - virology; Prognosis; Respiration; Respiratory diseases; Retrospective Studies; Risk analysis; Risk Factors; SARS-CoV-2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Sex; Signs and symptoms; Survival; Survival Rate; Tumors; Viral diseases; Italy; epidemiology; risk factors; outcome; coronavirus disease 2019 (COVID-19); hematologic patients
• ISSN: 0008-543X; 1097-0142; 1097-0142
• DOI: 10.1002/cncr.33160

Background Patients with cancer are considered highly vulnerable to the recent coronavirus disease 2019 (COVID‐19) pandemic. However, there are still few data on COVID‐19 occurring in hematologic patients. Methods One hundred two patients with COVID‐19 symptoms and a nasopharyngeal swab positive for severe acute respiratory syndrome coronavirus 2 seen at 2 hematologic departments located in Lombardy, Italy, during March 2020 were studied. Risk factors for acquiring COVID‐19 were analyzed by comparisons of patients with COVID‐19 and the standard hematologic population managed at the same institutions in 2019. Thirty‐day survival was compared with the survival of matched uninfected control patients with similar hematologic disorders and nonhematologic patients affected by COVID‐19. Results Male sex was significantly more prevalent in patients with COVID‐19. The infection occurred across all different types of hematologic disease; however, the risk of acquiring a COVID‐19 infection was lower for patients with chronic myeloproliferative neoplasms, including chronic myeloid leukemia, and higher for patients with immune‐mediated anemia on immunosuppressive‐related treatments. The 30‐day mortality rate was 39.2%, which was higher than the rates for nonhematologic patients with COVID‐19 (23.5%; P = .02) and uninfected hematologic controls (3%; P < .001). The severity of the respiratory syndrome at presentation and active hematologic treatment were independently associated with a worse prognosis. Neither diagnosis nor disease status affected the prognosis. The worst prognosis was demonstrated among patients on active hematologic treatment and those with more severe respiratory syndrome at COVID‐19 presentation. Conclusions During the COVID‐19 pandemic, patients should be advised to seek medical attention at the earliest signs of dyspnea and/or respiratory infection. Physicians should perform a risk‐benefit analysis to determine the impact of temporarily deferring nonlifesaving treatments versus the risk of adverse outcomes associated with COVID‐19. Lay Summary Coronavirus disease 2019 (COVID‐19) infection occurs across all different types of hematologic disease; however, the risk of acquiring it is lower for patients with chronic myeloproliferative neoplasms, including chronic myeloid leukemia, and higher for patients with immune‐mediated anemia on immunosuppressive treatment. The 30‐day mortality rate is 39.2%, which is far higher than the rates for both uninfected hematologic controls (3%; P < .001) and nonhematologic patients with COVID‐19 (23.5%; P = .02) despite matching for age, sex, comorbidities, and severity of disease. Variables independently associated with a worse prognosis are the severity of the respiratory syndrome at presentation and any type of active hematologic treatment. Neither diagnosis nor disease status influence the prognosis. Hematologic patients affected by coronavirus disease 2019 (COVID‐19) have a severe prognosis and a 30‐day mortality rate of 39.2%. The need for oxygen and ongoing hematologic treatment at the presentation of COVID‐19 are the main risk factors associated with a worse outcome.