Human papillomavirus typing and soluble interleukin-2 receptor levels in female sex workers with a negative cervical smear result

• Published in: International journal of gynecology and obstetrics Vol. 106; no. 3; pp. 210 - 212
• Main Authors: Arioz, Dagistan Tolga, Altindis, Mustafa, Tokyol, Cigdem, Kalayci, Raike, Saylan, Arif, Yilmazer, Mehmet
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.09.2009; Elsevier
• Subjects: Adult; Alphapapillomavirus - classification; Alphapapillomavirus - isolation & purification; Biological and medical sciences; Biomarkers - analysis; Case-Control Studies; Cervical smear; Female; Female sex workers; Gynecology. Andrology. Obstetrics; Human papillomavirus; Humans; Medical sciences; Obstetrics and Gynecology; Papillomavirus Infections - diagnosis; Receptors, Interleukin-2 - analysis; Sex Work; Soluble interleukin-2 receptor; Vaginal Smears; Soluble interleukin-2 receptor; Cervical smear; Female sex workers; Human papillomavirus; Typing; Gynecology; Papovaviridae; Uterine cervix; Obstetrics; Papillomavirus; Virus; Prostitution; Negative result; Microbiological investigation; Interleukin 2; Female
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1016/j.ijgo.2009.04.005

Abstract Objective To investigate the association between high-risk human papillomavirus (HPV) types and soluble interleukin-2 receptor (sIL-2R) levels in female sex workers with a negative cervical smear result, and to determine the effectiveness of using sIL-2R levels to screen for high-risk strains of HPV. Method A negative cervical smear result and a blood sample were obtained from 68 women: 43 female sex workers and 25 women acting as controls. HPV DNA genotyping was performed and sIL-2R levels were assessed. Results Female sex workers had significantly higher sIL-2R levels than women in the control group (318.37 ± 239.7 vs 114.4 ± 56.5 U/mL, respectively P < 0.001). In addition, female sex workers with high-risk strains of HPV had significantly higher sIL-2R levels than those who did not have high-risk strains of HPV (736.7 ± 251.5 vs 250.5 ± 156.1 U/mL, respectively; P = 0.001). Conclusion High sIL-2R levels may be useful in screening for high-risk strains of HPV in female sex workers who have a negative cervical smear result.