H2A.B facilitates transcription elongation at methylated CpG loci

• Published in: Genome research Vol. 24; no. 4; pp. 570 - 579
• Main Authors: Chen, Yibin, Chen, Qiang, McEachin, Richard C, Cavalcoli, James D, Yu, Xiaochun
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.04.2014
• Subjects: Animals; CpG Islands; DNA Methylation - genetics; Gene Expression Regulation; Genetic Variation; Genome; Histones - biosynthesis; Histones - genetics; Mice; Promoter Regions, Genetic; Transcription, Genetic

H2A.B is a unique histone H2A variant that only exists in mammals. Here we found that H2A.B is ubiquitously expressed in major organs. Genome-wide analysis of H2A.B in mouse ES cells shows that H2A.B is associated with methylated DNA in gene body regions. Moreover, H2A.B-enriched gene loci are activ...