Characterization of Uterine Leiomyomas by Whole-Genome Sequencing
Some leiomyomas have chromosomal rearrangements implicating chromothripsis, a process involving the formation of complex chromosomal rearrangements. In three instances, tumors obtained from the same woman were documented to be clonally related. Uterine leiomyomas are benign smooth-muscle tumors with...
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Published in | The New England journal of medicine Vol. 369; no. 1; pp. 43 - 53 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Waltham, MA
Massachusetts Medical Society
04.07.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Some leiomyomas have chromosomal rearrangements implicating chromothripsis, a process involving the formation of complex chromosomal rearrangements. In three instances, tumors obtained from the same woman were documented to be clonally related.
Uterine leiomyomas are benign smooth-muscle tumors with an estimated prevalence of 77% among women of reproductive age in the United States
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and can cause a range of health problems.
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According to a nationwide analysis of 518,828 hysterectomies performed in 2005 in the United States, 282,291 of the patients who underwent the procedure (54%) had leiomyomas.
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Hormonal factors, family history, African ancestry, and obesity increase the risk of leiomyomas.
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Presentation with multiple tumors is typical (an estimated average is six to seven
1
). Whether leiomyosarcomas develop from leiomyomas or arise independently is not known. Uterine leiomyosarcoma is very rare,
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and it . . . |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJMoa1302736 |