Targeting adaptive glioblastoma: an overview of proliferation and invasion

Glioblastoma is one of the most devastating cancers, in which tumor cell infiltration into surrounding normal brain tissue confounds clinical management. This review describes basic and translational research into glioma proliferation and invasion, in particular the phenotypic switch underlying a st...

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Published inNeuro-oncology (Charlottesville, Va.) Vol. 16; no. 12; pp. 1575 - 1584
Main Authors Xie, Qian, Mittal, Sandeep, Berens, Michael E
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.12.2014
Subjects
Brain Neoplasms - pathology
Brain Neoplasms - physiopathology
Brain Neoplasms - therapy
Cell Proliferation
Glioblastoma - pathology
Glioblastoma - physiopathology
Glioblastoma - therapy
Humans
Neoplasm Invasiveness - physiopathology
Reviews
targeted therapy
glioblastoma
invasion
proliferation
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Summary:Glioblastoma is one of the most devastating cancers, in which tumor cell infiltration into surrounding normal brain tissue confounds clinical management. This review describes basic and translational research into glioma proliferation and invasion, in particular the phenotypic switch underlying a stochastic "go or grow" model of tumor cell behavior. We include recent progress in system genomics, cancer stem cell theory, and tumor-microenvironment interaction, from which novel therapeutic strategies may emerge for managing this malignant disease. We suggest that an effective therapeutic strategy should target both adaptive glioblastoma cells and the stroma-tumor interaction.
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ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/nou147