Modulation of the arterial baroreceptor reflex by the vasopressin receptor in the area postrema of the hypertensive rats

• Published in: Neuroscience letters Vol. 226; no. 3; pp. 179 - 182
• Main Authors: Nakayama, Yasuhisa, Takano, Yukio, Eguchi, Kazuhide, Migita, Keisuke, Saito, Ryo, Tsujimoto, Gozoh, Kamiya, Hiro-o
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 02.05.1997; Elsevier
• Subjects: Animals; Area postrema; Arterial hypertension. Arterial hypotension; Baroreceptor reflex; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - physiology; Cardiology. Vascular system; Cerebral Ventricles - physiology; Experimental diseases; Hypertension - physiopathology; Hypertensive rats; Male; Medical sciences; Pressoreceptors - physiology; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Vasopressin - physiology; Reflex - physiology; Vasopressin receptor; Vasopressin V2 receptor mRNA; Baroreceptor reflex; Hypertensive rats; Area postrema; Vasopressin receptor; Vasopressin V2 receptor mRNA; Hypertension; Ependymal organ; Rat; Rodentia; Central nervous system; Cardiovascular disease; Neuropeptide; Vasopressin; Vertebrata; Mammalia; Animal; Baroreflex; Peptidergic receptor; Baroreceptor; Brain (vertebrata)
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(97)00274-7

The role of arginine 8-vasopressin (AVP) in regulation of the baroreceptor reflex in the area postrema was examined in anesthetized hypertensive rats. The sensitivity of the baroreceptor reflex in a one-kidney one clip (1K1C) hypertensive rats was increased in only the initial stage (2 weeks), in association with increase in blood pressure, and then returned to the normal level. This increase in the sensitivity of the baroreceptor reflex in the initial stage was reversed by microinjection of a V1 or V2 antagonist (1 μg) into the area postrema. AVP V2 receptor mRNA was expressed temporarily in the area postrema in this period. These results suggest that vasopressin receptors in the area postrema is important in regulating the sensitivity of the baroreceptor reflex.