Cortical Responses to Input From Distant Areas are Modulated by Local Spontaneous Alpha/Beta Oscillations

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 29; no. 2; pp. 777 - 787
• Main Authors: Usami, Kiyohide, Milsap, Griffin W, Korzeniewska, Anna, Collard, Maxwell J, Wang, Yujing, Lesser, Ronald P, Anderson, William S, Crone, Nathan E
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2019
• Subjects: Adolescent; Adult; Alpha Rhythm - physiology; Beta Rhythm - physiology; Cerebral Cortex - physiology; Drug Resistant Epilepsy - diagnosis; Drug Resistant Epilepsy - physiopathology; Electrocorticography - methods; Electrodes, Implanted; Female; Humans; Male; Original; single-pulse electrical stimulation; CCEP; high gamma; beta; alpha
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhx361

Abstract Any given area in human cortex may receive input from multiple, functionally heterogeneous areas, potentially representing different processing threads. Alpha (8-13 Hz) and beta oscillations (13-20 Hz) have been hypothesized by other investigators to gate local cortical processing, but their influence on cortical responses to input from other cortical areas is unknown. To study this, we measured the effect of local oscillatory power and phase on cortical responses elicited by single-pulse electrical stimulation (SPES) at distant cortical sites, in awake human subjects implanted with intracranial electrodes for epilepsy surgery. In 4 out of 5 subjects, the amplitudes of corticocortical evoked potentials (CCEPs) elicited by distant SPES were reproducibly modulated by the power, but not the phase, of local oscillations in alpha and beta frequencies. Specifically, CCEP amplitudes were higher when average oscillatory power just before distant SPES (−110 to −10 ms) was high. This effect was observed in only a subset (0-33%) of sites with CCEPs and, like the CCEPs themselves, varied with stimulation at different distant sites. Our results suggest that although alpha and beta oscillations may gate local processing, they may also enhance the responsiveness of cortex to input from distant cortical sites.