Anti-inflammatory Agents: Present and Future

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory a...

Full description

Saved in:
Bibliographic Details
Published inCell Vol. 140; no. 6; pp. 935 - 950
Main Author Dinarello, Charles A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.03.2010
Subjects
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - immunology
Anti-Inflammatory Agents - therapeutic use
Autoimmune Diseases - drug therapy
Blocking
Cancer
Disorders
Drug Design
Drugs
Histones
Humans
Immune systems
Inflammation - drug therapy
Inflammation - immunology
Inhibitors
Kinases
Online AccessGet full text

Cover

More Information
Summary:Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes “biologicals” such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
ISSN:0092-8674
1097-4172
0020-7683
1097-4172
DOI:10.1016/j.cell.2010.02.043