The Use and Effectiveness of Triple Multiplex System for Coding Region Single Nucleotide Polymorphism in Mitochondrial DNA Typing of Archaeologically Obtained Human Skeletons from Premodern Joseon Tombs of Korea

Previous study showed that East Asian mtDNA haplogroups, especially those of Koreans, could be successfully assigned by the coupled use of analyses on coding region SNP markers and control region mutation motifs. In this study, we tried to see if the same triple multiplex analysis for coding regions...

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Published inBioMed research international Vol. 2015; no. 2015; pp. 1 - 7
Main Authors Shin, Dong Hoon, Kim, Yi-Suk, Lee, Soong Deok, Oh, Chang Seok
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2015
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Asian Continental Ancestry Group - genetics
Bones
Chromosomes
Deoxyribonucleic acid
DNA
DNA, Mitochondrial - genetics
Female
Femur
Forensic Anthropology
Genetic aspects
Genetic Markers
History, 16th Century
History, 17th Century
History, 18th Century
Humans
Male
Medical research
Medicine
Methods
Mitochondrial DNA
Observations
Polymorphism, Single Nucleotide
Republic of Korea
Research methodology
Researchers
Single nucleotide polymorphisms
Skeleton
Studies
University colleges
Republic of Korea
South Korea
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Summary:Previous study showed that East Asian mtDNA haplogroups, especially those of Koreans, could be successfully assigned by the coupled use of analyses on coding region SNP markers and control region mutation motifs. In this study, we tried to see if the same triple multiplex analysis for coding regions SNPs could be also applicable to ancient samples from East Asia as the complementation for sequence analysis of mtDNA control region. By the study on Joseon skeleton samples, we know that mtDNA haplogroup determined by coding region SNP markers successfully falls within the same haplogroup that sequence analysis on control region can assign. Considering that ancient samples in previous studies make no small number of errors in control region mtDNA sequencing, coding region SNP analysis can be used as good complimentary to the conventional haplogroup determination, especially of archaeological human bone samples buried underground over long periods.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Otto Appenzeller
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/850648