Formulation and in vitro Evaluation of Floating Capsules of Theophylline
Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in...
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Published in | Indian journal of pharmaceutical sciences Vol. 70; no. 2; pp. 224 - 227 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
India
Medknow Publications and Media Pvt. Ltd
01.03.2008
Medknow Publications & Media Pvt. Ltd Medknow Publications |
Subjects | |
Online Access | Get full text |
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Summary: | Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitro drug release. All the four formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitro drug release study of these formulations indicated controlled release of theophylline and about 76 percent drug was released at the end of 12 h. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Bhise, et al.: Floating Capsules of Theophylline |
ISSN: | 0250-474X 1998-3743 |
DOI: | 10.4103/0250-474X.41460 |