Formulation and in vitro Evaluation of Floating Capsules of Theophylline

Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in...

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Bibliographic Details
Published inIndian journal of pharmaceutical sciences Vol. 70; no. 2; pp. 224 - 227
Main Authors Bhise, S B, Aloorkar, N H
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.03.2008
Medknow Publications & Media Pvt. Ltd
Medknow Publications
Subjects
Dosage and administration
Drug delivery systems
Drugs
Health aspects
Pharmacokinetics
Short Communications
Studies
Theophylline
Vehicles
India
sustained release
Theophylline
floating drug delivery system
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Summary:Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitro drug release. All the four formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitro drug release study of these formulations indicated controlled release of theophylline and about 76 percent drug was released at the end of 12 h.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Bhise, et al.: Floating Capsules of Theophylline
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.41460