Structural genomics and its importance for gene function analysis

Structural genomics projects aim to solve the experimental structures of all possible protein folds. Such projects entail a conceptual shift from traditional structural biology in which structural information is obtained on known proteins to one in which the structure of a protein is determined firs...

Full description

Saved in:
Bibliographic Details
Published inNature biotechnology Vol. 18; no. 3; pp. 283 - 287
Main Authors Skolnick, Jeffrey, Fetrow, Jacquelyn S, Kolinski, Andrzej
Format Journal Article
LanguageEnglish
Published New York, NY Nature 01.03.2000
Nature Publishing Group
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Structural genomics projects aim to solve the experimental structures of all possible protein folds. Such projects entail a conceptual shift from traditional structural biology in which structural information is obtained on known proteins to one in which the structure of a protein is determined first and the function assigned only later. Whereas the goal of converting protein structure into function can be accomplished by traditional sequence motif-based approaches, recent studies have shown that assignment of a protein's biochemical function can also be achieved by scanning its structure for a match to the geometry and chemical identity of a known active site. Importantly, this approach can use low-resolution structures provided by contemporary structure prediction methods. When applied to genomes, structural information (either experimental or predicted) is likely to play an important role in high-throughput function assignment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1087-0156
1546-1696
DOI:10.1038/73723