Single versus multiple dose intravenous immunoglobulin in combination with LED phototherapy in the treatment of ABO hemolytic disease in neonates

• Published in: International journal of hematology Vol. 93; no. 6; pp. 700 - 703
• Main Authors: Demirel, Gamze, Akar, Melek, Celik, Istemi Han, Erdeve, Omer, Uras, Nurdan, Oguz, Serife Suna, Dilmen, Ugur
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.06.2011; Springer; Springer Nature B.V
• Subjects: ABO system; Anemias. Hemoglobinopathies; Biological and medical sciences; Blood groups; Blood Transfusion, Autologous; Diseases of red blood cells; Erythroblastosis, Fetal - drug therapy; Erythroblastosis, Fetal - therapy; Erythrocyte Transfusion; Erythrocytes; Exchange Transfusion, Whole Blood; Female; Hematocrit; Hematologic and hematopoietic diseases; Hematology; Hemolysis; Hemolytic disease; Humans; Immunoglobulins; Immunoglobulins, Intravenous - administration & dosage; Immunologic Factors - administration & dosage; Infant; Infant, Newborn; Intensive Care Units, Neonatal; Intravenous administration; Jaundice; Jaundice, Neonatal - therapy; Male; Medical sciences; Medicine; Medicine & Public Health; Neonates; Oncology; Original Article; Phototherapy; Statistical analysis; Transfusion; IVIG; Newborn; ABO hemolytic disease; LED phototherapy; Human; Drug combination; Immunoglobulins; Intravenous administration; Hematology; ABO(H)-System; Single dose; Hemopathy; Phototherapy; Multiple dose; Blood group; Hemolytic anemia; Treatment; Comparative study
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-011-0853-4

Intravenous immunoglobulin (IVIG) has been found to decrease hemolysis in neonatal jaundice due to blood group incompatibility, but a consensus on its usage has not been reached. We conducted a study to compare single versus multiple dose of IVIG in combination with light emitting diode (LED) phototherapy in patients with neonatal jaundice secondary to ABO blood incompatibility, and compared the efficacy of these treatments with that in a group of patients who received LED phototherapy solely. Thirty-nine term neonates with ABO blood group incompatibility were enrolled in the study. Group I received one dose of IVIG (1 g/kg) and LED phototherapy, and group II two doses of IVIG (1 g/kg) and LED phototherapy, whereas group III received LED phototherapy only. In group I, exchange transfusion was performed in one patient (6%) and in group II in one patient (10%). In the control group, none of the patients required exchange transfusion. Duration of LED phototherapy was 4.3 ± 0.7 days in group I + II (IVIG group), 3.9 ± 0.6 days in group III ( P = 0.06). Lowest hematocrit level in group I + II was 35.0 ± 7.8 and group III was 38.9 ± 4.2, this was statistically significant ( P = 0.034). IVIG therapy, single or multiple, did not affect exchange transfusion, need of erythrocyte transfusion and hospitalization time when used in combination with LED phototherapy in the treatment of ABO hemolytic jaundice in neonates.