Effect of leucine at different levels of pyridoxine on hepatic quinolinate phosphoribosyl transferase (EC 2.4.2.19) and leucine aminotransferase (EC 2.6.1.6) in rats
1. Effects of incorporating 30 g leucine/kg into diets on quinolinate phosphoribosyl transferase (QPRT; EC 2.4.2.19) activity and leucine aminotransferase (EC 2.6.1.6) activity were studied in groups of rats receiving 5, 30 and 60 μg of pyridoxine/10 g diet. 2. The results indicated that 30 g leucin...
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Published in | British journal of nutrition Vol. 39; no. 1; pp. 61 - 64 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Cambridge, UK
Cambridge University Press
01.01.1978
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Subjects | |
Online Access | Get full text |
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Summary: | 1. Effects of incorporating 30 g leucine/kg into diets on quinolinate phosphoribosyl transferase (QPRT; EC 2.4.2.19) activity and leucine aminotransferase (EC 2.6.1.6) activity were studied in groups of rats receiving 5, 30 and 60 μg of pyridoxine/10 g diet. 2. The results indicated that 30 g leucine/kg diet significantly reduced the QPRT activity when the diets provided 5 μg pyridoxine/10 g and that the effect was only marginal when the diet included 30 μg pyridoxine/ 10 g. The inhibitory effect was completely absent when the diet provided higher amounts of pyridoxine (60 μg/10g). 3. These results suggest that additional amounts of pyridoxine are necessary to counteract the effects of excess of leucine in the diet. 4. Leucine aminotransferase activity was increased in rats given diets containing higher amounts of pyridoxine; supplementary leucine also increased the enzyme activity. |
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Bibliography: | ArticleID:00094 ark:/67375/6GQ-H2Z2CGCC-B istex:2BA6CBB61D2DA22FA90D317DC88F90C95066E857 PII:S000711457800094X ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-1145 1475-2662 |
DOI: | 10.1079/BJN19780012 |