Emergence of Zaire Ebola Virus Disease in Guinea

• Published in: The New England journal of medicine Vol. 371; no. 15; pp. 1418 - 1425
• Main Authors: Baize, Sylvain, Pannetier, Delphine, Oestereich, Lisa, Rieger, Toni, Koivogui, Lamine, Magassouba, N'Faly, Soropogui, Barrè, Sow, Mamadou Saliou, Keïta, Sakoba, De Clerck, Hilde, Tiffany, Amanda, Dominguez, Gemma, Loua, Mathieu, Traoré, Alexis, Kolié, Moussa, Malano, Emmanuel Roland, Heleze, Emmanuel, Bocquin, Anne, Mély, Stephane, Raoul, Hervé, Caro, Valérie, Cadar, Dániel, Gabriel, Martin, Pahlmann, Meike, Tappe, Dennis, Schmidt-Chanasit, Jonas, Impouma, Benido, Diallo, Abdoul Karim, Formenty, Pierre, Van Herp, Michel, Günther, Stephan
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 09.10.2014
• Series: Brief Report
• Subjects: Adolescent; Adult; Archives & records; Base Sequence; Biological and medical sciences; Child; Diarrhea; Disease Outbreaks; Ebola virus; Ebolavirus; Ebolavirus - classification; Ebolavirus - genetics; Ebolavirus - isolation & purification; Epidemics; Epidemiology; Fatalities; Female; Fever; General aspects; Genomes; Guinea - epidemiology; Hemorrhagic Fever, Ebola - epidemiology; Hemorrhagic Fever, Ebola - virology; Hospitalization; Hospitals; Humans; Laboratories; Male; Medical sciences; Microscopy; Outbreaks; Phylogenetics; Phylogeny; Public health; RNA, Viral - analysis; Software; Viruses; Vomiting; Young Adult; Guinea; Congo (Democratic republic); Africa; Guinea (country); Zaire; Germany; Sudan; Virus; Medicine; Ebola virus; Mononegavirales; Filoviridae; Filovirus; Epidemiology
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa1404505

In March 2014, an outbreak of Ebola virus disease associated with a high fatality rate was identified in Guinea, with evidence of ongoing person-to-person transmission. In this update to the preliminary report, the virus is found to be a new strain related to Zaire ebolavirus . Outbreaks caused by viruses of the genera ebolavirus and marburgvirus represent a major public health issue in sub-Saharan Africa. Ebola virus disease is associated with a case fatality rate of 30 to 90%, depending on the virus species. Specific conditions in hospitals and communities in Africa facilitate the spread of the disease from human to human. Three ebolavirus species have caused large outbreaks in sub-Saharan Africa: EBOV, Sudan ebolavirus, and the recently described Bundibugyo ebolavirus . 1 , 2 Epidemics have occurred in the Democratic Republic of Congo, Sudan, Gabon, Republic of Congo, and Uganda. Reston ebolavirus circulates in the Philippines. It . . .