Clinical and pathologic features of lung cancer expressing programmed cell death ligand 1 (PD-L1)

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 98; pp. 69 - 75
• Main Authors: Shimoji, Masaki, Shimizu, Shigeki, Sato, Katsuaki, Suda, Kenichi, Kobayashi, Yoshihisa, Tomizawa, Kenji, Takemoto, Toshiki, Mitsudomi, Tetsuya
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2016
• Subjects: Adenocarcinoma; Adenocarcinoma - diagnosis; Adenocarcinoma - genetics; Adenocarcinoma of Lung; Aged; Aged, 80 and over; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Biomarkers, Tumor; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - genetics; EMT; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression; Hematology, Oncology and Palliative Medicine; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lung cancer; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - mortality; Lung Neoplasms - therapy; Male; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; PD-L1; Prognosis; Prognostic factor; Proportional Hazards Models; Pulmonary/Respiratory; RNA, Messenger - genetics; PD-L1; adenocarcinoma; prognostic factor; EMT; Lung cancer; Adenocarcinoma; Prognostic factor
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/j.lungcan.2016.04.021

Highlights • A correlation between PD-L1 mRNA expression and H-score was strong in cell lines. • PD-L1 was expressed in 22% of adenocarcinomas and 60% of squamous cell cancers. • PD-L1 expression was associated with high proliferation and EMT in adenocarcinoma. • PD-L1 expression was a significant poor prognostic factor in lung adenocarcinoma.