Therapeutic effects of bone marrow-derived mesenchymal stem cells on radiation-induced lung injury

• Published in: Oncology reports Vol. 35; no. 2; pp. 731 - 738
• Main Authors: XIA, CHENGCHENG, CHANG, PENGYU, ZHANG, YUYU, SHI, WEIYAN, LIU, BIN, DING, LIJUAN, LIU, MIN, GAO, LING, DONG, LIHUA
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.02.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adipocytes; Animals; Bone marrow; Bone Marrow Cells; bone marrow-derived mesenchymal stem cells; Care and treatment; Cell Differentiation - physiology; Complications and side effects; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique; Growth factors; Health aspects; Heterografts; Humans; Lung cancer; Lung diseases; Medical prognosis; Mesenchymal Stem Cell Transplantation - methods; Mice; Radiation Injuries, Experimental - complications; Radiation Injuries, Experimental - surgery; radiation pneumonitis; Radiation Pneumonitis - surgery; radiation pulmonary fibrosis; Radiotherapy; Real-Time Polymerase Chain Reaction; Stem cells; thoracic tumor; Tissue engineering; Tumor necrosis factor-TNF; Veins & arteries; United States > US; China

Radiation-induced lung injury (RILI) is a fatal condition featured by interstitial pneumonitis and fibrosis. Mesenchymal stem cells (MSCs) have been widely used for treating RILI in rodent models. In the present study, we aimed to investigate whether the therapeutic effects of human bone marrow-deri...