Bactericidal effect of cethromycin (ABT-773) in an immunocompetent murine pneumococcal pneumonia model

The efficacy of cethromycin was assessed against isolates of Streptococcus pneumoniae in the presence of neutrophils. Comparison with data from our previous neutropenic model revealed that the presence of neutrophils enhanced the bacteriostatic and bactericidal effect of cethromycin by an average of...

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Bibliographic Details
Published inInternational journal of antimicrobial agents Vol. 22; no. 6; pp. 588 - 593
Main Authors Capitano, Blair, Maglio, Dana, Banevicius, Mary Anne, Nightingale, Charles H., Nicolau, David P.
Format Journal Article
LanguageEnglish
Published London Elsevier B.V 01.12.2003
Amsterdam Elsevier
New York, NY
Subjects
Animals
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteriocidal
Bacteriostatic
Biological and medical sciences
Cethromycin
Colony Count, Microbial
Disease Models, Animal
Erythromycin - analogs & derivatives
Erythromycin - pharmacology
Female
Immunocompetence
Ketolide
Ketolides
Medical sciences
Mice
Mice, Inbred CBA
Neutropenia - immunology
Neutropenia - microbiology
Neutrophil
Neutrophils - immunology
Pharmacology. Drug treatments
Pneumonia, Pneumococcal - drug therapy
Pneumonia, Pneumococcal - immunology
Pneumonia, Pneumococcal - microbiology
Streptococcus pneumoniae
Streptococcus pneumoniae - drug effects
Streptococcus pneumoniae - isolation & purification
Cethromycin
Neutrophil
Bacteriocidal
Ketolide
Bacteriostatic
Streptococcus pneumoniae
Animal model
Pharmacokinetic pharmacodynamic relationship
Pneumonia
Streptococcal infection
Bacteria
Micrococcales
Pneumococcal infection
Lung disease
Respiratory disease
Rodentia
Biological activity
Bactericidal effect
Infection
Streptococcaceae
Vertebrata
Antibiotic
Mammalia
Mouse
Bacteriosis
Antibacterial agent
Pharmacokinetics
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Summary:The efficacy of cethromycin was assessed against isolates of Streptococcus pneumoniae in the presence of neutrophils. Comparison with data from our previous neutropenic model revealed that the presence of neutrophils enhanced the bacteriostatic and bactericidal effect of cethromycin by an average of two- to four-times, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(03)00156-0