Bactericidal effect of cethromycin (ABT-773) in an immunocompetent murine pneumococcal pneumonia model
The efficacy of cethromycin was assessed against isolates of Streptococcus pneumoniae in the presence of neutrophils. Comparison with data from our previous neutropenic model revealed that the presence of neutrophils enhanced the bacteriostatic and bactericidal effect of cethromycin by an average of...
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Published in | International journal of antimicrobial agents Vol. 22; no. 6; pp. 588 - 593 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
Elsevier B.V
01.12.2003
Amsterdam Elsevier New York, NY |
Subjects | |
Online Access | Get full text |
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Summary: | The efficacy of cethromycin was assessed against isolates of
Streptococcus pneumoniae in the presence of neutrophils. Comparison with data from our previous neutropenic model revealed that the presence of neutrophils enhanced the bacteriostatic and bactericidal effect of cethromycin by an average of two- to four-times, respectively. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0924-8579 1872-7913 |
DOI: | 10.1016/S0924-8579(03)00156-0 |