Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats

• Published in: Acta radiologica (1987) Vol. 49; no. 10; p. 1174
• Main Authors: Baik, S K, Kim, Y-W, Kim, H J, Lee, J W, Cho, B M, Kim, D-H, Choi, S H, Lee, S H, Chang, K H
• Format: Journal Article
• Language: English
• Published: England 01.12.2008
• Subjects: Animals; Aspartic Acid - analogs & derivatives; Aspartic Acid - analysis; Aspartic Acid - metabolism; Brain - metabolism; Cats; Choline - analysis; Choline - metabolism; Contrast Media; Creatine - analysis; Creatine - metabolism; Disease Models, Animal; Disease Progression; Embolism, Fat - chemically induced; Embolism, Fat - diagnosis; Embolism, Fat - metabolism; Follow-Up Studies; Gadolinium DTPA; Image Enhancement - methods; Intracranial Embolism - chemically induced; Intracranial Embolism - diagnosis; Intracranial Embolism - metabolism; Lactic Acid - analysis; Lactic Acid - metabolism; Lipid Metabolism - drug effects; Lipids; Magnetic Resonance Imaging - methods; Magnetic Resonance Spectroscopy - methods; Sodium Chloride - administration & dosage; Triolein - administration & dosage
• ISSN: 1600-0455
• DOI: 10.1080/02841850802512449

In experimental studies, embolization of the cerebral hemisphere with triolein emulsion has revealed reversible magnetic resonance imaging (MRI) findings in the subacute stage. To investigate the changes in the major metabolites, by proton magnetic resonance spectroscopy (MRS), in a cerebral fat embolism induced by a triolein emulsion. The internal carotid arteries of 19 cats were injected with a triolein emulsion, and multivoxel MRS was performed 30 min, 1 day, and 7 days later. In the control group, six cats were injected with normal saline. The MR spectra were evaluated for N-acetyl aspartate (NAA), creatine (Cr), and choline (Cho), along with the presence of lipid and lactate. Semiquantitative analyses of NAA/Cr, Cho/Cr, NAA/Cho, and lipid/Cr ratios compared the median values of the ipsilateral metabolite ratios with those of the contralateral side and in the control group for each point in time. The NAA/Cr, Cho/Cr, and NAA/Cho ratios in the ipsilateral cerebral hemisphere of the embolized group after 30 min, 1 day, and 7days were not significantly different from the contralateral hemisphere of the embolized and control groups (P>0.05). The lipid/Cr ratio in the ipsilateral cerebral hemisphere of the embolized group was significantly higher when compared with the control group (P=0.012 at 30 min, P=0.001 on day 1, and P=0.018 on day 7). Cerebral fat embolism induced by a triolein emulsion resulted in no significant change in the major metabolites of the brain in the acute stage, except for an elevated lipid/Cr ratio, which suggests the absence of any significant hypoxic-ischemic changes in the lesions embolized using a fat emulsion.