The chick embryo chorioallantoic membrane as a model for tumor biology

Among the in vivo models, the chick embryo chorioallantoic membrane (CAM) has been used to implant several tumor types as well as malignant cell lines to study their growth rate, angiogenic potential and metastatic capability. This review article is focused on the major compelling literature data on...

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Bibliographic Details
Published inExperimental cell research Vol. 328; no. 2; pp. 314 - 324
Main Author Ribatti, Domenico
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2014
Elsevier BV
Subjects
Angiogenesis
Animals
Chick Embryo - pathology
Chorioallantoic membrane
Chorioallantoic Membrane - pathology
Embryos
Humans
Membranes
Metastasis
Neoplasm Metastasis - pathology
Neoplasms - pathology
Neovascularization, Pathologic - pathology
Poultry
Tumor growth
Tumorigenesis
Angiogenesis
Metastasis
Chorioallantoic membrane
Tumor growth
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Summary:Among the in vivo models, the chick embryo chorioallantoic membrane (CAM) has been used to implant several tumor types as well as malignant cell lines to study their growth rate, angiogenic potential and metastatic capability. This review article is focused on the major compelling literature data on the use of the CAM to investigate tumor growth and the metastatic process. •The chick embryo CAM is a model for tumor biology and metastasis.•Being naturally immunodeficient, the chick embryo may receive transplantations from different tissues and species.•Compared with mammals models, tumor growth in the CAM is faster.•In contrast to standard mouse models most cancer cells complete extravasation within 24h after injections in the CAM.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2014.06.010