Role of tissue factor in embryonic blood vessel development

Tissue factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor for plasma factor VII/VIIa (ref. 1), is the primary cellular initiator of blood coagulation. It is involved in thrombosis and inflammation associated with sepsis, atherosclerosis and cancer, and can...

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Published inNature (London) Vol. 383; no. 6595; pp. 73 - 75
Main Authors Carmeliet, Peter, Mackman, Nigel, Moons, Lieve, Luther, Thomas, Gressens, Pierre, Van Vlaenderen, Lise, Demunck, Hilde, Kasper, Michael, Breier, Georg, Evrard, Philippe, Müller, Martin, Risau, Werner, Edgington, Thomas, Collen, Désiré
Format Journal Article
LanguageEnglish
Published London Nature Publishing 05.09.1996
Nature Publishing Group
Subjects
Animals
Biological and medical sciences
Blood
Blood Vessels - embryology
Blood vessels and receptors
Chromosome Mapping
Coagulation
Culture Techniques
Embryonic growth stage
Embryos
Fetal Death
Fundamental and applied biological sciences. Psychology
Gene Targeting
Genes
Inactivation
Medical research
Mice
Regional Blood Flow
Thromboembolism
Thromboplastin - genetics
Thromboplastin - physiology
Tissues
Vertebrates: cardiovascular system
Yolk Sac - blood supply
Yolk Sac - ultrastructure
Embryonic development
Yolk sac
Vertebrata
Mammalia
Mouse
Blood vessel
Rodentia
Tissue factor
Circulatory system
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Summary:Tissue factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor for plasma factor VII/VIIa (ref. 1), is the primary cellular initiator of blood coagulation. It is involved in thrombosis and inflammation associated with sepsis, atherosclerosis and cancer, and can participate in other cellular processes including intracellular signalling, metastasis, tumor-associated angiogenesis, and embryogenesis. Here we report that inactivation of the tissue factor gene (TF) results in abnormal circulation from yolk sac to embryo beyond embryonic day 8.5, leading to embryo wasting and death. Vitelline vessels from null mice were deficient in smooth-muscle alpha-actin-expressing mesenchymal cells, which participate in organization of the vessel wall. This implies that tissue factor has a role in blood vessel development.
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ISSN:0028-0836
1476-4687
DOI:10.1038/383073a0