Enflurane and isoflurane stimulate calcium transport by cardiac sarcoplasmic reticulum

The authors' recent report has demonstrated that halothane can either stimulate or inhibit SR calcium uptake. These effects were related to the concentration of adenosine triphosphate (ATP), the substrate and energy source for the transport of calcium. At low ATP concentrations halothane in inc...

Full description

Saved in:
Bibliographic Details
Published inAnesthesia and analgesia Vol. 61; no. 2; pp. 142 - 145
Main Authors Blanck, T J, Thompson, M
Format Journal Article
LanguageEnglish
Published United States 01.01.1982
Subjects
Adenosine Triphosphate - metabolism
Biological Transport, Active - drug effects
calcium
Calcium - metabolism
enflurane
Enflurane - pharmacology
Halothane - pharmacology
heart
In Vitro Techniques
isoflurane
Isoflurane - pharmacology
Kinetics
Methyl Ethers - pharmacology
Myocardium - metabolism
sarcoplasmic reticulum
Sarcoplasmic Reticulum - drug effects
Sarcoplasmic Reticulum - metabolism
Online AccessGet full text

Cover

More Information
Summary:The authors' recent report has demonstrated that halothane can either stimulate or inhibit SR calcium uptake. These effects were related to the concentration of adenosine triphosphate (ATP), the substrate and energy source for the transport of calcium. At low ATP concentrations halothane in increasing concentrations first stimulated and then inhibited Ca super(2+) uptake; at higher ATP concentrations halothane only inhibited calcium uptake. In this paper the authors describe some similar effects of enflurane and isoflurane on SR calcium uptake, and the possible common mechanism of action of these volatile anesthetics.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0003-2999
DOI:10.1213/00000539-198202000-00015