Development of Transition-Metal-Catalysed Cross-Coupling Reactions through Ammonium C–N Bond Cleavage

• Published in: Chemical & pharmaceutical bulletin Vol. 68; no. 8; pp. 683 - 693
• Main Author: Wang, Chao
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.08.2020; Japan Science and Technology Agency
• Subjects: Ammonium; Ammonium Compounds - chemistry; Biological Products - chemical synthesis; Biological Products - chemistry; Carbon - chemistry; carbon–nitrogen bond cleavage; Catalysis; Chemical reactions; Cleavage; computational chemistry; Computer applications; Coupling (molecular); Cross coupling; Density Functional Theory; Ductile-brittle transition; Hydrogen - chemistry; naturally abundant chemical; Reaction mechanisms; synthetic method; Transition Elements - chemistry; transition metal catalysis; Transition metals; cross-coupling; naturally abundant chemical; synthetic method; transition metal catalysis; computational chemistry; carbon–nitrogen bond cleavage

In this review, we summarize our recent progress on functionalization of the ammonium C–N bond through a transition-metal-catalysed cross-coupling process. By synergistic utilization of computational and experimental methods, we have successfully developed several new C–N bond cleavage protocols and...