Development of Transition-Metal-Catalysed Cross-Coupling Reactions through Ammonium C–N Bond Cleavage

• Published in: Chemical & pharmaceutical bulletin Vol. 68; no. 8; pp. 683 - 693
• Main Author: Wang, Chao
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.08.2020; Japan Science and Technology Agency
• Subjects: Ammonium; Ammonium Compounds - chemistry; Biological Products - chemical synthesis; Biological Products - chemistry; Carbon - chemistry; carbon–nitrogen bond cleavage; Catalysis; Chemical reactions; Cleavage; computational chemistry; Computer applications; Coupling (molecular); Cross coupling; Density Functional Theory; Ductile-brittle transition; Hydrogen - chemistry; naturally abundant chemical; Reaction mechanisms; synthetic method; Transition Elements - chemistry; transition metal catalysis; Transition metals; cross-coupling; naturally abundant chemical; synthetic method; transition metal catalysis; computational chemistry; carbon–nitrogen bond cleavage
• ISSN: 0009-2363; 1347-5223; 1347-5223
• DOI: 10.1248/cpb.c20-00196

In this review, we summarize our recent progress on functionalization of the ammonium C–N bond through a transition-metal-catalysed cross-coupling process. By synergistic utilization of computational and experimental methods, we have successfully developed several new C–N bond cleavage protocols and established new reaction mechanisms. These findings provide new possibilities for transforming naturally abundant chemicals into useful functional molecules in an efficient and selective manner.