Lipase-Mediated Resolution of Inden-1-ol

Optically pure inden-1-ol has been obtained efficiently in both enantiomeric forms via kinetic deacylation of racemic 1-acetoxyindene using lipase PS.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 43; no. 9; pp. 1585 - 1587
Main Authors TAKAHASHI, Michiyasu, KOIKE, Rie, OGASAWARA, Kunio
Format Journal Article
LanguageEnglish
Published TOKYO The Pharmaceutical Society of Japan 1995
Pharmaceutical Soc Japan
Maruzen
Subjects
Alicyclic compounds
Alicyclic compounds, terpenoids, prostaglandins, steroids
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
cis-1-aminoindan-2-ol
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
inden-1-ol, 1-acetoxyindene
Life Sciences & Biomedicine
lipase-mediated kinetic resolution
Methods. Procedures. Technologies
Organic chemistry
Pharmacology & Pharmacy
Physical Sciences
Preparations and properties
Science & Technology
ALCOHOLS
CIS-1-AMINOINDAN-2-OL
LIPASE-MEDIATED KINETIC RESOLUTION
INDEN-1-OL,1-ACETOXYINDENE
Phosphates
Aminoalcohol
Enzyme
Triacylglycerol lipase
Esterases
Buffer solution
Carboxylic ester hydrolases
Hydrolysis
Organic solvent
Optical resolution
Bicyclic compound
Hydrolases
Aromatic compound
Kinetics
Secondary alcohol
Acylate
Acetone
Enzymatic reaction
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Summary:Optically pure inden-1-ol has been obtained efficiently in both enantiomeric forms via kinetic deacylation of racemic 1-acetoxyindene using lipase PS.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.43.1585