The Occurrence of Apparent Bilateral Aldosterone Suppression in Adrenal Vein Sampling for Primary Aldosteronism

• Published in: Journal of the Endocrine Society Vol. 2; no. 5; pp. 398 - 407
• Main Authors: Shibayama, Yui, Wada, Norio, Naruse, Mitsuhide, Kurihara, Isao, Ito, Hiroshi, Yoneda, Takashi, Takeda, Yoshiyu, Umakoshi, Hironobu, Tsuiki, Mika, Ichijo, Takamasa, Fukuda, Hisashi, Katabami, Takuyuki, Yoshimoto, Takanobu, Ogawa, Yoshihiro, Kawashima, Junji, Ohno, Yuichi, Sone, Masakatsu, Fujita, Megumi, Takahashi, Katsutoshi, Shibata, Hirotaka, Kamemura, Kohei, Fujii, Yuichi, Yamamoto, Koichi, Suzuki, Tomoko
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.05.2018
• Subjects: Clinical s; adrenal vein sampling; aldosterone suppression; apparent bilateral; hypertension; primary aldosteronism
• ISSN: 2472-1972; 2472-1972
• DOI: 10.1210/js.2017-00481

Abstract Context In adrenal venous sampling (AVS) for patients with primary aldosteronism (PA), apparent bilateral aldosterone suppression (ABAS), defined as lower aldosterone/cortisol ratios in the bilateral adrenal veins than that in the inferior vena cava, is occasionally experienced. ABAS is uninterpretable with respect to lateralization of excess aldosterone production. We previously reported that ABAS was not a rare phenomenon and was significantly reduced after adrenocorticotropic hormone (ACTH) administration. Objective To validate the effects of ACTH administration and adding sampling positions in the left adrenal vein on the prevalence of ABAS in the larger Japan Primary Aldosteronism Study. Patients The data from 1689 patients with PA who underwent AVS between January 2006 and October 2016 were studied. All patients in the previous study, the West Japan Adrenal Vein Sampling study, were excluded. Outcome Measurements The prevalence of ABAS was investigated at two sampling positions in the left adrenal vein, the central vein and the common trunk, without and with ACTH administration. Results The prevalence of ABAS with ACTH administration was significantly lower than that without ACTH administration [without ACTH vs with ACTH: 79/440 (18.0%) vs 45/591 (7.6%); P < 0.001]. With ACTH administration, the prevalence of ABAS was not different between the sampling position, at the central vein and at the common trunk [33/591 (5.6%) vs 32/591 (5.4%); P = 1.00]. Conclusions The effectiveness of ACTH administration for the reduction of ABAS in AVS regardless of the sampling position in the left adrenal vein was confirmed in the larger cohort. We validated the effect of ACTH administration on resolving ABAS, defined as lower aldosterone/cortisol ratios in the bilateral adrenal veins than that in the inferior vena cava.