Nck Links Nephrin to Actin in Kidney Podocytes

Two papers, one in Nature ( Jones et al., 2006) and the other in the Journal of Clinical Investigation ( Verma et al., 2006) show that Nck adaptor proteins connect phosphorylated nephrin with actin polymerization in podocyte foot processes, structures important for slit-diaphragm formation in the ki...

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Bibliographic Details
Published inCell Vol. 125; no. 2; pp. 221 - 224
Main Authors Tryggvason, Karl, Pikkarainen, Timo, Patrakka, Jaakko
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 21.04.2006
Subjects
Actins - metabolism
Adaptor Proteins, Signal Transducing
Animals
Cells, Cultured
Cytoskeleton - metabolism
Kidney Glomerulus - cytology
Kidney Glomerulus - metabolism
Kidney Glomerulus - pathology
Medicin och hälsovetenskap
Membrane Proteins - metabolism
Mice
Oncogene Proteins - metabolism
Podocytes - cytology
Podocytes - metabolism
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Summary:Two papers, one in Nature ( Jones et al., 2006) and the other in the Journal of Clinical Investigation ( Verma et al., 2006) show that Nck adaptor proteins connect phosphorylated nephrin with actin polymerization in podocyte foot processes, structures important for slit-diaphragm formation in the kidney. Their results further our understanding of podocyte development and repair in glomerular disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2006.04.002