Ocular diseases： immunological and molecular mechanisms

Many factors, such as environmental, microbial and endogenous stress, antigen localization, can trigger the immunological events that affect the ending of the diverse spectrum of ocular disorders. Significant advances in understanding of immunological and molecular mechanisms have been researched to...

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Bibliographic Details
Published inInternational journal of ophthalmology Vol. 9; no. 5; pp. 780 - 788
Main Authors Song, Jing, Huang, Yi-Fei, Zhang, Wen-Jing, Chen, Xiao-Fei, Guo, Yu-Mian
Format Journal Article
LanguageEnglish
Published China International Journal of Ophthalmology Press 18.05.2016
Press of International Journal of Ophthalmology (IJO PRESS)
Subjects
chemokines
immune response
immunological mechanism
ocular diseases
Review
systemic autoimmunity
chemokines
immunological mechanism
immune response
ocular diseases
systemic autoimmunity
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Summary:Many factors, such as environmental, microbial and endogenous stress, antigen localization, can trigger the immunological events that affect the ending of the diverse spectrum of ocular disorders. Significant advances in understanding of immunological and molecular mechanisms have been researched to improve the diagnosis and therapy for patients with ocular inflammatory diseases. Some kinds of ocular diseases are inadequately responsive to current medications;therefore, immunotherapy may be a potential choice as an alternative or adjunctive treatment, even in the prophylactic setting. This article first provides an overview of the immunological and molecular mechanisms concerning several typical and common ocular diseases; second, the functions of immunological roles in some of systemic autoimmunity will be discussed; third, we will provide a summary of the mechanisms that dictate immune cell trafficking to ocular local microenvironment in response to inflammation.
Bibliography:immunological mechanism; ocular diseases; systemic autoimmunity; immune response; chemokines
Many factors, such as environmental, microbial and endogenous stress, antigen localization, can trigger the immunological events that affect the ending of the diverse spectrum of ocular disorders. Significant advances in understanding of immunological and molecular mechanisms have been researched to improve the diagnosis and therapy for patients with ocular inflammatory diseases. Some kinds of ocular diseases are inadequately responsive to current medications;therefore, immunotherapy may be a potential choice as an alternative or adjunctive treatment, even in the prophylactic setting. This article first provides an overview of the immunological and molecular mechanisms concerning several typical and common ocular diseases; second, the functions of immunological roles in some of systemic autoimmunity will be discussed; third, we will provide a summary of the mechanisms that dictate immune cell trafficking to ocular local microenvironment in response to inflammation.
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ObjectType-Review-1
ISSN:2222-3959
2227-4898
DOI:10.18240/ijo.2016.05.25