Lactic acid as an invaluable green solvent for ultrasound-assisted scalable synthesis of pyrrole derivatives

• Published in: Ultrasonics sonochemistry Vol. 26; pp. 81 - 86
• Main Authors: Wang, Shi-Fan, Guo, Chao-Lun, Cui, Ke-ke, Zhu, Yan-Ting, Ding, Jun-Xiong, Zou, Xin-Yue, Li, Yi-Hang
• Format: Journal Article
• Language: English
• Published: AMSTERDAM Elsevier B.V 01.09.2015; Elsevier
• Subjects: Acoustics; Bio-based solvent; Chemistry; Chemistry Techniques, Synthetic; Chemistry, Multidisciplinary; Green Chemistry Technology - methods; Lactic acid; Lactic Acid - chemistry; Physical Sciences; Pyrrole derivative; Pyrroles - chemical synthesis; Pyrroles - chemistry; Scalable Knorr condensation; Science & Technology; Solvents - chemistry; Technology; Ultrasonic radiation; Ultrasonic Waves; Ultrasonic radiation; Lactic acid; Pyrrole derivative; Bio-based solvent; Scalable Knorr condensation; ONE-POT; N-SUBSTITUTED PYRROLES; CATALYST; IRRADIATION; 4-COMPONENT SYNTHESIS; SULFATE; CHEMISTRY; IONIC LIQUIDS; EFFICIENT

Lactic acid has been used as a bio-based green solvent to study the ultrasound-assisted scale-up synthesis. We report here, for the first time, on the novel and scalable process for synthesis of pyrrole derivatives in lactic acid solvent under ultrasonic radiation. Eighteen pyrrole derivatives have...