Glucose metabolism in gastric cancer： The cutting-edge

Glucose metabolism in gastric cancer cells differsfrom that of normal epithelial cells. Upregulatedaerobic glycolysis （Warburg effect） in gastric cancermeeting the demands of cell proliferation is associatedwith genetic mutations, epigenetic modification andproteomic alteration. Understanding the me...

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Published inWorld journal of gastroenterology : WJG Vol. 22; no. 6; pp. 2046 - 2059
Main Author Yuan, Lian-Wen
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 14.02.2016
Subjects
Animals
Antineoplastic Agents - therapeutic use
Biomarker
Biomarkers, Tumor - metabolism
cancer
Cell Hypoxia
Cell Proliferation
effect;Metabolomics
Gastric
Glucose
Glucose - metabolism
Glycolysis - drug effects
Humans
metabolism
Metabolomics
Molecular Targeted Therapy
Review
Signal Transduction
Stomach Neoplasms - drug therapy
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Therapy
Tumor Microenvironment
Warburg
Glucose metabolism
Metabolomics
Therapy
Biomarker
Gastric cancer
Warburg effect
Online AccessGet full text
ISSN1007-9327
2219-2840
DOI10.3748/wjg.v22.i6.2046

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Summary:Glucose metabolism in gastric cancer cells differsfrom that of normal epithelial cells. Upregulatedaerobic glycolysis （Warburg effect） in gastric cancermeeting the demands of cell proliferation is associatedwith genetic mutations, epigenetic modification andproteomic alteration. Understanding the mechanisms ofaerobic glycolysis may contribute to our knowledge ofgastric carcinogenesis. Metabolomic studies offer novel,convenient and practical tools in the search for newbiomarkers for early detection, diagnosis, prognosis,and chemosensitivity prediction of gastric cancer.Interfering with the process of glycolysis in cancercells may provide a new and promising therapeuticstrategy for gastric cancer. In this article, we presenta brief review of recent studies of glucose metabolismin gastric cancer, with primary focus on the clinicalapplications of new biomarkers and their potentialtherapeutic role in gastric cancer.
Bibliography:Correspondence to: Lian-Wen Yuan, MD, PhD, Associate Professor, Visiting Researcher, Department of Geriatrics Surgery, Second Xiangya Hospital, Center-South University, Yuelu District, 932 South Lushan Rd, Changsha 410011, Hunan Province, China. yuanlianwen1971@aliyun.com
Author contributions: Yuan LW performed the literature search and wrote the review; Yamashita H and Seto Y participated in revising the review.
Telephone: +86-731-85295167 Fax: +86-731-5362966
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i6.2046