Biological screening of araripe basin medicinal plants using Artemia salina Leach and pathogenic bacteria
Many medicinal plant species from the Araripe Basin are widely known and used in folk medicine and for commercial manufacturing of phytotherapeutic products. Few ethnobotanical and pharmacological studies have been undertaken in this region, however, in spite of the great cultural and biological div...
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Published in | Pharmacognosy Magazine Vol. 6; no. 24; pp. 331 - 334 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
India
Medknow Publications and Media Pvt. Ltd
01.10.2010
Sage Publications Ltd Medknow Publications |
Subjects | |
Online Access | Get full text |
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Summary: | Many medicinal plant species from the Araripe Basin are widely known and used in folk medicine and for commercial manufacturing of phytotherapeutic products. Few ethnobotanical and pharmacological studies have been undertaken in this region, however, in spite of the great cultural and biological diversity found there.
Extracts of 11 plant species collected from Ceará state, Brazil, were subjected to the brine shrimp lethality test in order to detect potential sources of novel cytotoxic, antitumor compounds. The larvicidal activity, based on the percentage of larval mortality, was evaluated after 24 h exposure to the treatments.
All species tested showed good larvicidal activity as compared to a reference compound and literature data. The extract from Vanillosmopsis arborea was the most active with an LC(50) of 3.9 μg/ml. Best results were shown by Lantana montevidensis against Pseudomonas aeruginosa [minimum inhibitory concentration (MIC) 8μg/ml] and Escherichia coli (MIC 32 μg/ml), Zanthoxylum rhoifolium against E. coli (MIC, 256 μg/ml) and Staphylococcus aureus (MIC 64 μg/ml) and Croton zenhtneri against S. aureus (MIC 64 μg/ml).
Chemical tests indicated that a wide variety of natural product classes was present in those extracts that showed significant activities in the bioassays. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0973-1296 0976-4062 |
DOI: | 10.4103/0973-1296.71792 |