Living-Neuron-Based Autogenerator

We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain s...

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Published inSensors (Basel, Switzerland) Vol. 23; no. 16; p. 7016
Main Authors Gerasimova, Svetlana A., Beltyukova, Anna, Fedulina, Anastasia, Matveeva, Maria, Lebedeva, Albina V., Pisarchik, Alexander N.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2023
MDPI
Subjects
Alzheimer's disease
Analysis
Arrays
autogenerator
Brain research
Catecholamines
Cell culture
close-loop control system
Closed loop systems
Control theory
Deep brain stimulation
Feedback
hippocampal slice
hybrid neural circuit
Neural networks
neuron-like oscillator
Neurons
Parkinson's disease
Physiology
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Summary:We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain slices. The local field potentials generated by the living neurons trigger a transition in the FitzHugh–Nagumo circuit from an excitable state to an oscillatory mode, and in turn, the spikes produced by the electronic circuit synchronize with the living-neuron spikes. The key advantage of this hybrid electrobiological autogenerator lies in its capability to control biological neuron signals, which holds significant promise for diverse neuromorphic applications.
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ISSN:1424-8220
1424-8220
DOI:10.3390/s23167016