Non-coding RNAs as direct and indirect modulators of epigenetic regulation

• Published in: Epigenetics Vol. 9; no. 1; pp. 3 - 12
• Main Authors: Peschansky, Veronica J, Wahlestedt, Claes
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2014; Landes Bioscience
• Subjects: chromatin; DNA Methylation - genetics; DNA Modification Methylases - genetics; DNA Modification Methylases - metabolism; Epigenesis, Genetic; epigenetics; gene expression; Gene Silencing; histone; Histones - genetics; Histones - metabolism; Humans; lncRNA; microRNA; noncoding RNA; piRNA; polycomb; Polycomb-Group Proteins - genetics; Polycomb-Group Proteins - metabolism; Review; RNA, Untranslated - classification; RNA, Untranslated - genetics; RNA, Untranslated - metabolism; lncRNA; noncoding RNA; piRNA; polycomb; microRNA; histone; chromatin; epigenetics; gene expression
• ISSN: 1559-2294; 1559-2308; 1559-2308
• DOI: 10.4161/epi.27473

Epigenetic regulation of gene expression is an increasingly well-understood concept that explains much of the contribution of an organism's environment and experience to its biology. However, discussion persists as to which mechanisms can be classified as epigenetic. Ongoing research continues to uncover novel pathways, including the important role of non-protein coding RNA transcripts in epigenetic gene regulation. We know that the majority of human and other mammalian transcripts are not translated but that many of these are nonetheless functional. These non-coding RNAs (ncRNAs) can be short (< 200 nt) or long (< 200 nt) and are further classified by genomic origin and mechanism of action. We discuss examples of ncRNAs that interact with histone modifying complexes or DNA methyltransferases to regulate gene expression, others that are targets of these epigenetic mechanisms, and propose a model in which such transcripts feed back into an epigenetic regulatory network.