Expanding the range of ‘druggable’ targets with natural product-based libraries: an academic perspective

Existing drugs address a relatively narrow range of biological targets. As a result, libraries of drug-like molecules have proven ineffective against a variety of challenging targets, such as protein–protein interactions, nucleic acid complexes, and antibacterial modalities. In contrast, natural pro...

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Published inCurrent opinion in chemical biology Vol. 14; no. 3; pp. 308 - 314
Main Authors Bauer, Renato A, Wurst, Jacqueline M, Tan, Derek S
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2010
Subjects
Animals
DNA-Binding Proteins
Drug Delivery Systems - methods
Drug Discovery - methods
Drugs
High-Throughput Screening Assays
Humans
Protein Interaction Mapping
Small Molecule Libraries
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Summary:Existing drugs address a relatively narrow range of biological targets. As a result, libraries of drug-like molecules have proven ineffective against a variety of challenging targets, such as protein–protein interactions, nucleic acid complexes, and antibacterial modalities. In contrast, natural products are known to be effective at modulating such targets, and new libraries are being developed based on underrepresented scaffolds and regions of chemical space associated with natural products. This has led to several recent successes in identifying new chemical probes that address these challenging targets.
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ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2010.02.001