Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk

• Published in: Open medicine (Warsaw, Poland) Vol. 18; no. 1; p. 20230655
• Main Authors: Yan, Shouchun, Wu, Shouzhen, Wu, Jia, Zhang, Qinlu, He, Yongjun, Jiang, Chao, Jin, Tianbo
• Format: Journal Article
• Language: English
• Published: Poland De Gruyter 09.03.2023; Walter de Gruyter GmbH
• Subjects: Apoptosis; Breast cancer; Chi-square test; Chromosomes; Colorectal cancer; Confidence intervals; Emergency medical care; Gender; Genes; Hospitals; Laboratories; Lung cancer; Lung diseases; Medical prognosis; Medicine; MRPS30-DT; NINJ2; Regression analysis; single-nucleotide polymorphisms; Software; lung cancer; single-nucleotide polymorphisms; NINJ2; MRPS30-DT
• ISSN: 2391-5463; 2391-5463
• DOI: 10.1515/med-2023-0655

Lung cancer is one of the malignant tumors, and genetic background is a risk factor in lung cancer that cannot be neglected. In this study, we aimed to find out the effect of MRPS30-DT and NINJ2 variants on lung cancer risk. In this study, the seven selected single-nucleotide polymorphisms (SNPs) of MRPS30-DT and NINJ2 were genotyped in 509 lung cancer patients and 501 healthy controls based on the Agena MassARRAY platform. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to evaluate association between gene polymorphisms and lung cancer risk. False-positive report probability was also used to assess false-positive results. Furthermore, the interaction between SNPs was analyzed by multifactor dimensionality reduction to predict lung cancer risk. We identified the genotype TA of rs16901963 (T < A) in MRPS30-DT as a protective factor against lung cancer, while rs16901963-TT was significantly associated with an increased risk of lung cancer. We also revealed that the effect of MRPS30-DT and NINJ2 variants on the risk of lung cancer was dependent on age, gender, smoking, and drinking status. In conclusion, this study first proved that MRPS30-DT and NINJ2 variants played important roles in affecting the susceptibility to lung cancer.