Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy

Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation. The hemochorial placenta facilitates the acquisition of maternal resources required for embryo/fetal growth. Uterine spiral arteries form the nutrient supply line for the placenta and fetus. This vascular...

Full description

Saved in:
Bibliographic Details
Published inThe International journal of developmental biology Vol. 58; no. 2-4; pp. 247 - 259
Main Authors Soares, Michael J, Chakraborty, Damayanti, Kubota, Kaiyu, Renaud, Stephen J, Rumi, M A Karim
Format Journal Article
LanguageEnglish
Published Spain 2014
Subjects
Adaptation, Physiological
Animals
Female
Humans
Maternal-Fetal Exchange
Placenta - blood supply
Pregnancy
Trophoblasts - cytology
Trophoblasts - physiology
Uterine Artery - cytology
Uterine Artery - physiology
Uterus - blood supply
Uterus - cytology
Online AccessGet full text

Cover

More Information
Summary:Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation. The hemochorial placenta facilitates the acquisition of maternal resources required for embryo/fetal growth. Uterine spiral arteries form the nutrient supply line for the placenta and fetus. This vascular conduit undergoes gestation stage-specific remodeling directed by maternal natural killer cells and embryo-derived invasive trophoblast lineages. The placentation site, including remodeling of the uterine spiral arteries, is shaped by environmental challenges. In this review, we discuss the cellular participants controlling pregnancy-dependent uterine spiral artery remodeling and mechanisms responsible for their development and function.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0214-6282
1696-3547
DOI:10.1387/ijdb.140083ms