Candida peritonitis due to peptic ulcer perforation: incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B

• Published in: Diagnostic microbiology and infectious disease Vol. 44; no. 1; pp. 23 - 27
• Main Authors: Lee, Sai-Cheong, Fung, Chang-Phone, Chen, Huang-Yang, Li, Chiung-Tsung, Jwo, Shyh-Chuan, Hung, Yi-Ben, See, Lai-Chu, Liao, How-Chin, Loke, Song-Seng, Wang, Feng-Lin, Lee, Jenq-Chang
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2002; Elsevier
• Subjects: Adult; Age Distribution; Aged; Amphotericin B - administration & dosage; Ascitic Fluid - microbiology; Biological and medical sciences; Candida - drug effects; Candida - isolation & purification; Cohort Studies; Female; Fluconazole - administration & dosage; Human mycoses; Humans; Incidence; Infectious diseases; Male; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Mycoses; Mycoses of the digestive system; Peptic Ulcer Perforation - complications; Peptic Ulcer Perforation - microbiology; Peritonitis - drug therapy; Peritonitis - epidemiology; Peritonitis - microbiology; Probability; Prospective Studies; Risk Factors; Sex Distribution; Statistics, Nonparametric; Survival Rate; Taiwan - epidemiology; Taiwan; Candidiasis; Yeast; Prognosis; Mycosis; Fluconazole; Perforation; Incidence; Fungi; Infection; Antibiotic; Antifungal agent; Sensitivity resistance; Amphotericin B; Polyenic compound; Abdominal disease; Candida; Parasiticid; Risk factor; Triazole derivatives; Digestive diseases; Fungi Imperfecti; Peritonitis; Thallophyta
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/S0732-8893(02)00419-4

Sixty-two cases of peritonitis due to peptic ulcer perforation were diagnosed between January 2000 and December 2000. Of these 62 cases, 23 isolates of Candida in 23 cases (CP) were cultured from peritoneal fluid. Cultures of peritoneal fluid of 10 (BP) of the remaining 39 cases was positive for bacteria only. Cultures of peritoneal fluid of the remaining 29 cases was negative. Comparison of CP, BP and culture-negative cases did not reveal any significant risk factor. Of the 23 Candida isolates, the Candida species and 48-h MICs of fluconazole and amphotericin B (mean, range ug/ml) were C. albicans 18 (0.688, 0.125–1.0; 0.297, 0.031–0.5), C. glabrata 3 (0.542, 0.125–1.0; 0.25, 0.125–0.5), C. tropicalis 1 (0.25; 0.5), C. intermedia 1 (1.0; 0.125) respectively. Mortality rates of CP, BP and culture-negative peritonitis due to infection were 5/23(21.7%), 0/10 and 1/29(3.4%) respectively. Without effective antifungal therapy, the mortality rate of CP was not low.