A 4 year prospective study to determine risk factors for severe community acquired pneumonia in children in southern China

• Published in: Pediatric pulmonology Vol. 48; no. 4; pp. 390 - 397
• Main Authors: Zhang, Qingli, Guo, Zhongqin, Bai, Zhenjiang, MacDonald, Noni E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2013; Wiley Subscription Services, Inc
• Subjects: acute lower respiratory tract infection; Adolescent; Cardiovascular disease; Child; Child, Preschool; children; China; China - epidemiology; Community acquired pneumonia; Community-Acquired Infections - etiology; Community-Acquired Infections - mortality; Community-Acquired Infections - therapy; Critical Care - methods; Critical Care - statistics & numerical data; developing country; Fatalities; Female; Hospitalization - statistics & numerical data; hospitalized; Hospitals, Pediatric - statistics & numerical data; Humans; Infant; intensive care; Intensive Care Units, Pediatric - statistics & numerical data; Logistic Models; Male; Multivariate analysis; Original : Respiratory Infections; Pneumonia - etiology; Pneumonia - mortality; Pneumonia - therapy; Prospective Studies; Risk Factors; Severity of Illness Index; Streptococcus infections; Treatment Outcome; China
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.22608

Background Pneumonia is the major cause of death under 5 years. With high CAP numbers in China and growing access to PICUs, factors associated with severe CAP need to be determined to optimize care. Objective To prospectively determine PICU CAP admission features and outcomes. Methods A 4 year prospective study of CAP aged 1 month to <14 years admitted to PICU, Children's Hospital Affiliated to Soochow University, China. All were managed in a standard manner. Clinical, laboratory, and imaging findings were collected systematically. All received antibiotics. Results Eight hundred ten (7%) of 10,836 CAP hospital admissions needed PICU. Seven hundred seven (87%) were enrolled. PICU CAP children were young (76% ≤ 12 months) and 33% had co‐morbid conditions; 21% congenital heart disease.21% required mechanical ventilation. The average length of PICU stay was 5 days (range, 3–27). The case fatality rate was 5.8%. Viruses were detected in 38%, RSV 24%; bacteria in 23%, Streptococcus pneumoniae 7%, Haemophilus influenza b 4%, Mycoplasma 11%. On single factor analysis, PICU admission respiratory rate >70/min, grunting/groaning, head nodding, cyanosis, and anemia were associated with respiratory failure and with fatality. On multivariate analysis only presence of congenital heart disease, Trisomy 21 and immunodeficiency correlated with fatality; not microbe nor PICU findings. Conclusions Young age and underlying congenital heart disease were associated factors for PICU support in CAP in China. Early referral if altered sensorium, high respiratory rate, head nodding, grunting and anemia, and universal access to conjugated vaccines may decrease morbidity and mortality. Pediatr Pulmonol. 2013; 48:390–397. © 2012 Wiley Periodicals, Inc.