Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer

• Published in: Case reports in obstetrics and gynecology Vol. 2020; no. 2020; pp. 1 - 6
• Main Authors: Cotes, Martha, Casadiego, Camila, Vallard, Alexis, Magne, Nicolas, Molano, Monica, Carrillo, Schyrly, Mayorga, Diana, Acosta, Jinneth, Huertas, Antonio, Vial, Nicolas, Romero-Rojas, Alfredo, Moreno-Acosta, Pablo, Gamboa, Oscar
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; Hindawi Limited; Wiley
• Subjects: Age; Asian Americans; Biomarkers; Biopsy; Cancer research; Case Report; Case reports; Cell cycle; Cervical cancer; Cervix; Development and progression; Gene expression; Human papillomavirus; Infections; Papillomavirus infections; Polymorphism; Protein expression; Proteins; Risk factors; Sexual intercourse; Sexually transmitted diseases; Squamous cell carcinoma; Tumor proteins; Womens health; Colombia
• ISSN: 2090-6684; 2090-6692
• DOI: 10.1155/2020/6806857

This article is a preliminary investigational study that is aimed at giving hints about the interesting biomarkers involved in the transition process from low-grade cervix lesion to invasive cervical cancer. Our study focuses on the risk factors and tumour molecular changes in one patient. First in 1986, she was diagnosed a preinvasive cervix lesion. Then, 16 years later, she was diagnosed an invasive cervical cancer. The 2002 diagnosis was a squamous cell carcinoma of the cervix, stage IIIB (FIGO), whereas in 1986, she had been diagnosed a high-grade squamous intraepithelial cervical lesion. Retrospectively, the analysis of samples of preneoplastic lesions and invasive cervical cancer confirmed the histopathological diagnoses and detected the presence of HPV type and HPV-16 variants, as well as the overexpression of proteins such as hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1. Finally, the Arg72Pro polymorphism was detected in TP53. The role of high-risk HPV and HPV-16 variants and of hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1 variations seemed confirmed in the development and progression of cervical cancer. As a result, analyzing the molecular changes in one and same tumour that progresses from a low-grade cervix lesion to invasive cervical cancer could provide valuable information in order to improve detection, diagnosis, and treatment in the future.