Oncolytic potential of rodent parvoviruses for cancer therapy in humans: a brief review

Rodent parvoviruses are promising candidates for oncolytic virotherapy of cancer in humans because of their oncotropism (preferential killing of transformed cells) in the absence of pathogenicity. Here, we give an overview concerning the possible application of parvovirus H-1 for cancer therapy, wit...

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Published inJournal of veterinary medicine. Series B Vol. 52; no. 7-8; pp. 327 - 330
Main Authors Geletneky, K, Herrero y Calle, M, Rommelaere, J, Schlehofer, J.R
Format Journal Article
LanguageEnglish
Published Berlin, Germany Blackwell Verlag GmbH 01.09.2005
Blackwell Publishing Ltd
Subjects
Animal diseases
animal models
Animals
anticarcinogenic activity
Antineoplastic Agents - therapeutic use
Cancer
carcinogenesis
cytotoxicity
H-1 parvovirus
human diseases
Humans
literature reviews
malignant glioma
Medical treatment
neoplasms
new methods
Oncolytic Virotherapy
Parvoviridae Infections - veterinary
Parvoviridae Infections - virology
Parvovirus
Rats
Rodent Diseases - virology
Rodents
therapeutics
Tumors
virology
Viruses
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Summary:Rodent parvoviruses are promising candidates for oncolytic virotherapy of cancer in humans because of their oncotropism (preferential killing of transformed cells) in the absence of pathogenicity. Here, we give an overview concerning the possible application of parvovirus H-1 for cancer therapy, with specific emphasis on malignant brain tumours in humans.
Bibliography:ark:/67375/WNG-MTKM2FK9-M
ArticleID:ZPH877
istex:D9502C976908BD9A1AB1A9CA69A14B0966D5E73F
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0931-1793
1863-1959
1439-0450
1863-2378
DOI:10.1111/j.1439-0450.2005.00877.x