Effects of intranasal kinetic oscillation stimulation on heart rate variability

• Published in: ANNALS OF NONINVASIVE ELECTROCARDIOLOGY Vol. 23; no. 1
• Main Authors: Jerling, Markus, Cygankiewicz, Iwona, Al‐Tawil, Nabil, Darpo, Borje, Ljungström, Anders, Zareba, Wojciech
• Format: Journal Article Publication
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2018; John Wiley and Sons Inc
• Subjects: Adult; Allergic rhinitis; Autonomic nervous system; Electrocardiography, Ambulatory - methods; Female; Headache; healthy subjects; Heart rate; Heart Rate - physiology; heart rate variability; Humans; intranasal; kinetic oscillation stimulation; Kinetics; Male; Medical instruments; Middle Aged; Migraine; Nasal Cavity; Nose; Original; Oscillations; Physical Stimulation - instrumentation; Physical Stimulation - methods; Reduction; Rhinitis; Stimulation; Variability; Very Low Frequencies; Young Adult; intranasal; healthy subjects; heart rate variability; kinetic oscillation stimulation
• ISSN: 1082-720X; 1542-474X; 1542-474X
• DOI: 10.1111/anec.12474

Background Kinetic oscillation stimulation in the nasal cavity (KOS) has been shown to have positive symptomatic effects in subjects with non‐allergic rhinitis and in patients with migraine. Methods To evaluate the effect of KOS on autonomic function, we assessed heart rate variability (HRV) in this small exploratory study in 12 healthy subjects. KOS treatment was performed using a minimally invasive system with a single‐use catheter inserted into the nasal cavity. During treatment, the tip was inflated and oscillated with a mean pressure of 95 millibar and amplitude of the oscillations of 100 millibar at a frequency of 68 Hz. Treatment was given for 15 minutes sequentially on each side. Heart rate variability was assessed during five 30‐minutes periods before, during and immediately after KOS treatment and 3.5 hours thereafter. KOS resulted in a substantial reduction of HRV. Results As compared to baseline recorded during 30 minutes preceding treatment, VLF was reduced by 65%, LF by 55%, the ratio LF/HF by 44%, with somewhat smaller observed effects in the time domain; SDNN and RMSDD were reduced by of 36% and 18%, respectively. Heart rate remained stable during treatment with minimal mean changes from 68 ± 7 bpm before to 68 ± 9 and 69 ± 9 bpm during and after treatment. Reduction of HRV parameters was consistently seen in all subjects, with rapid onset and return towards baseline values during post‐treatment observation periods. Conclusions KOS has an effect on the autonomic balance with pronounced heart‐rate independent reduction on HRV.