Calciphylaxis in a patient without renal failure or elevated parathyroid hormone: possible aetiological role of chemotherapy

Calciphylaxis is a rare, often fatal disease characterized clinically by progressive cutaneous necrosis and ulceration, and histologically by vascular calcification and thrombosis. It has been described in association with end‐stage renal disease, after initiation of dialysis, following renal transp...

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Bibliographic Details
Published inBritish journal of dermatology (1951) Vol. 143; no. 5; pp. 1087 - 1090
Main Authors Goyal, S., Huhn, K.M., Provost, T.T.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Ltd 01.11.2000
Blackwell
Oxford University Press
Subjects
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Biological and medical sciences
Breast Neoplasms - drug therapy
calciphylaxis
Calciphylaxis - chemically induced
chemotherapy
Dermatology
Drug Eruptions - etiology
Fatal Outcome
Female
Humans
Leg Ulcer - chemically induced
Medical sciences
Middle Aged
protein C
protein S
Skin involvement in other diseases. Miscellaneous. General aspects
Antineoplastic agent
Case study
Human
Skin disease
Calciphylaxis
Treatment
Parathyroid hormone
Toxicity
Deficiency
Protein C
Skin
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Summary:Calciphylaxis is a rare, often fatal disease characterized clinically by progressive cutaneous necrosis and ulceration, and histologically by vascular calcification and thrombosis. It has been described in association with end‐stage renal disease, after initiation of dialysis, following renal transplantation, and in patients with hyperparathyroidism. We present the first case of calciphylaxis occurring in a patient with both normal renal function and parathyroid hormone level and discuss the possible aetiological role of chemotherapy‐induced functional protein C and protein S deficiency.
ISSN:0007-0963
1365-2133
DOI:10.1046/j.1365-2133.2000.03853.x