Effect of Physiological Determinants and Cardiac Disease on Plasma Adiponectin Concentrations in Dogs

• Published in: Journal of veterinary internal medicine Vol. 28; no. 6; pp. 1738 - 1745
• Main Authors: Damoiseaux, C., Merveille, A.-C., Krafft, E., Da Costa, A.M., Gomart, S., Jespers, P., Michaux, C., Clercx, C., Verhoeven, C., Mc Entee, K.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2014; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Adipokines; Adiponectin - blood; Age; Animals; Biomarkers; Body fat; Cardiomyopathy; Cardiomyopathy, Dilated - blood; Cardiomyopathy, Dilated - physiopathology; Cardiomyopathy, Dilated - veterinary; Cardiovascular disease; Case-Control Studies; Dilated cardiomyopathy; Dog Diseases - blood; Dog Diseases - diagnostic imaging; Dog Diseases - physiopathology; Dogs; Dogs - blood; Dogs - physiology; Echocardiography - veterinary; Female; Heart Diseases - blood; Heart Diseases - diagnostic imaging; Heart Diseases - physiopathology; Heart Diseases - veterinary; Heart failure; Insulin resistance; Male; Metabolic syndrome; Metabolites; Mitral Valve Prolapse - blood; Mitral Valve Prolapse - physiopathology; Mitral Valve Prolapse - veterinary; Molecular weight; Mortality; Myxomatous mitral valve disease; Neuter status; Obesity; Plasma; Weight control; Myxomatous mitral valve disease; Dilated cardiomyopathy; Adipokines; Neuter status; Age
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/jvim.12433

Background In humans, a high concentration of adiponectin is associated with a favorable cardiovascular risk profile whereas, in patients with heart failure (HF), a high concentration of adiponectin is associated with a less favorable prognosis. Hypothesis/Objectives To evaluate the physiological determinants of plasma adiponectin concentration in dogs and the influence of heart disease, myxomatous mitral valve disease (MMVD), and dilated cardiomyopathy (DCM). Animals One hundred and fourteen client‐owned dogs and 9 Beagles from the research colony of the Clinical Veterinary Unit of the University of Liège. Methods We prospectively measured circulating adiponectin concentration in healthy control dogs (n = 77), dogs with MMVD (n = 22) and dogs with DCM (n = 15) of various degrees of severity. Diagnosis was confirmed by Doppler echocardiography. Plasma adiponectin concentration was measured by a canine‐specific sandwich ELISA kit. Results An analysis of covariance showed an association between adiponectin concentration and age, neuter status, and heart disease. No association between adiponectin concentration and class of HF, sex, body condition score, body weight, circadian rhythm, or feeding was found. Plasma adiponectin concentration was negatively correlated with age (P = .001). Adiponectin was lower in neutered (P = .008) compared to intact dogs. Circulating adiponectin concentration was increased in dogs with DCM compared to healthy dogs (P = .018) and to dogs with MMVD (P = .014). Conclusions and Clinical Importance Age and neutering negatively influence circulating adiponectin concentration. Plasma adiponectin concentration increased in dogs with DCM. Additional research is required to investigate if this hormone is implicated in the pathophysiology of DCM and associated with clinical outcome.