Decreased Clostridium Abundance after Electroconvulsive Therapy in the Gut Microbiota of a Patient with Schizophrenia

Relationships between gut microbiota and various disease pathogeneses have been investigated, but those between the pathogeneses of mental illnesses, including schizophrenia, and gut microbiota have only recently attracted attention. We observed a change in the gut microbiota of a patient with schiz...

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Bibliographic Details
Published inCase reports in psychiatry Vol. 2019; no. 2019; pp. 1 - 4
Main Authors Miyaoka, Tsuyoshi, Hashioka, Sadayuki, Hayashida, Maiko, Kanayama, Misako, Inagaki, Masatoshi
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2019
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Antipsychotic drugs
Antipsychotics
Blood
Brain research
Case Report
Case reports
Constipation
Disease
Drugs
Electroconvulsive therapy
Health aspects
Medical research
Medicine, Experimental
Mental disorders
Microbiota
Microbiota (Symbiotic organisms)
NMR
Nuclear magnetic resonance
Patients
Physiology
Psychotropic drugs
Schizophrenia
Science
Studies
Substance abuse treatment
Japan
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Summary:Relationships between gut microbiota and various disease pathogeneses have been investigated, but those between the pathogeneses of mental illnesses, including schizophrenia, and gut microbiota have only recently attracted attention. We observed a change in the gut microbiota of a patient with schizophrenia after administering electroconvulsive therapy (ECT). A 59-year-old woman was diagnosed with schizophrenia at 17 years of age and has been taking antipsychotic drugs since the diagnosis. Clostridium, which occupied 86.5% of her bacterial flora, decreased to 72.5% after 14 ECT sessions, while Lactobacillus increased from 1.2% to 5.5%, and Bacteroides increased from 9.1% to 31.5%. Previous studies have shown that Clostridium spp. are increased in patients with schizophrenia compared with those in healthy individuals and that Clostridium is reduced after pharmacological treatment. Our report is the first report on the gut microbiota of a patient with schizophrenia receiving ECT. Our results indicate that studies focusing on Clostridium to clarify the pathogenesis of schizophrenia as well as potential therapeutic mechanisms may be beneficial. However, further studies are needed.
Bibliography:Academic Editor: Michael Kluge
ISSN:2090-682X
2090-6838
DOI:10.1155/2019/4576842