The Pap smear for detection of bacterial vaginosis

• Published in: International journal of gynecology and obstetrics Vol. 98; no. 1; pp. 20 - 23
• Main Authors: Karani, A, De Vuyst, H, Luchters, S, Othigo, J, Mandaliya, K, Chersich, M.F, Temmerman, M
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.07.2007; Elsevier Science
• Subjects: Adult; Bacterial diseases; Bacterial diseases of the genital system; Bacterial vaginosis; Biological and medical sciences; Diagnostic accuracy; Female; Gentian Violet; Gynecology. Andrology. Obstetrics; Human bacterial diseases; Humans; Infectious diseases; Kenya - epidemiology; Medical sciences; Obstetrics and Gynecology; Pap smears; Papanicolaou Test; Phenazines; Prevalence; Prospective Studies; Reference Standards; Sensitivity and Specificity; Sub-Saharan Africa; Vaginal Smears - methods; Vaginosis, Bacterial - diagnosis; Vaginosis, Bacterial - epidemiology; Sub-Saharan Africa; Africa; Kenya; Sensitivity and specificity; Bacterial vaginosis; Pap smears; Diagnostic accuracy; Sub-Saharan Africa; Andrology; Gynecology; Cervical smear; Vaginal diseases; Obstetrics; Female genital diseases; Infection; Accuracy; Sensitivity; Specificity; Bacteriosis; Diagnosis; Detection
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1016/j.ijgo.2007.03.010

Abstract Objective To assess validity of Pap smears in diagnosing bacterial vaginosis. Method A prospective diagnostic accuracy study with 533 women in Mombasa, Kenya. Diagnosis of bacterial vaginosis using clinical observations scored with simplified Amsel's criteria and Bethesda system for Pap smears was compared with a reference standard (Nugent criteria for gram stains). Both laboratory tests were interpreted blindly. Result Bacterial vaginosis prevalence was 36.7% (191/521) with Nugent criteria. Pap smear sensitivity and specificity were 59.4% (111/187) and 83.3% (270/324), with corresponding figures for simplified Amsel's criteria of 44.8% (81/181) and 84.8% (263/310). For Pap smear and simplified Amsel's criteria, positive predictive values were 67.3 and 63.3%, and negative predictive values 78.0% and 72.5%. Conclusion In diagnosing bacterial vaginosis, Pap smears have moderate sensitivity (though higher than simplified Amsel's criteria). Specificity of Pap smears is adequate. Including bacterial vaginosis assessment as a standard component of Pap smears warrants consideration.