Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases

• Published in: Journal of medical virology Vol. 83; no. 8; pp. 1383 - 1390
• Main Authors: Goto, Akiteru, Li, Chih-Ping, Ota, Satoshi, Niki, Toshiro, Ohtsuki, Yuji, Kitajima, Shinichi, Yonezawa, Suguru, Koriyama, Chihaya, Akiba, Suminori, Uchima, Hisataka, Lin, Yueh-Min, Yeh, Kun-Tu, Koh, Jae-Soo, Kim, Chul-Woo, Kwon, Kun-Yong, Nga, Min En, Fukayama, Masashi
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; Asia; Asia - epidemiology; Biological and medical sciences; Carcinoma - virology; esophageal cancer; Esophageal Neoplasms - virology; Female; Fundamental and applied biological sciences. Psychology; Genotype; geographical distribution; human papillomavirus (HPV); human papillomavirus (HPV), Asia; Human viral diseases; Humans; In Situ Hybridization; Infectious diseases; lung cancer; Lung Neoplasms - virology; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Polymerase Chain Reaction; Prevalence; Viral diseases; Virology; Asia; Lung disease; human papillomavirus (HPV), Asia; esophageal cancer; Respiratory disease; Lung cancer; Esophageal disease; Papovaviridae; Malignant tumor; Esophagus cancer; geographical distribution; Papillomavirus; Virus; Human papillomavirus; Digestive diseases; Bronchus disease; Cancer
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.22150

The role of human papillomavirus (HPV) in the development of lung and esophageal cancer remains inconclusive, which is in contrast to the established role HPV plays in the development of uterine cervical cancer. One of the reasons for this is the difference among reported HPV infection rates in these cancers. An analysis of 485 lung and esophageal cancers (176 lung squamous cell carcinoma, 128 lung adenocarcinoma, 181 esophageal carcinoma) in eight institutions in Asia (Tokyo, Kochi, Kagoshima, and Okinawa, Japan; Seoul and Daegu, Korea; Changhua, Republic of China (Taiwan); Singapore, Singapore) was carried out in order to clarify infection rates with HPV. Samples were examined in one laboratory of the Department of Pathology, the University of Tokyo, Japan in order to avoid inter‐laboratory variation using a combination of polymerase chain reaction and in situ hybridization (ISH). HPV was found in 6.3%, 7%, and 9.4% of patients with lung squamous cell carcinoma, lung adenocarcinoma, and esophageal cancer, respectively. Among the geographic areas surveyed, Kagoshima exhibited a significantly higher prevalence of HPV infection in cases of esophageal carcinoma (24.1%). There was no geographical difference in the infection rates of HPV in lung carcinomas. Subtype‐specific ISH was also performed, which identified the high‐risk HPV types 16/18 in the majority (75.7%) of the patients with lung and esophageal cancer positive for HPV. J. Med. Virol. 83:1383–1390, 2011. © 2011 Wiley‐Liss, Inc.