Vestibular and Hearing Manifestations of Phenytoin Toxicity: A Retrospective Series

• Published in: Ear, nose, & throat journal Vol. 80; no. 6; pp. 404 - 409
• Main Authors: De Diego, Juan I., Prim, Maria P., Marcos, Sol, De Sarria, Maria J., Arpa, Javier, Gavilan, Javier
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.06.2001; Medquest Communications; Sage Publications, Inc; SAGE PUBLICATIONS, INC
• Subjects: Adolescent; Adult; Age Distribution; Anticonvulsants - adverse effects; Anticonvulsants - therapeutic use; Biological and medical sciences; Complications and side effects; Drug toxicity and drugs side effects treatment; Female; Hearing; Hearing Disorders - chemically induced; Humans; Incidence; Male; Medical sciences; Medicine; Middle Aged; Otolaryngology; Pharmacology. Drug treatments; Phenytoin; Phenytoin - adverse effects; Phenytoin - therapeutic use; Practice; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Seizures - drug therapy; Sex Distribution; Toxicity: respiratory system, ent, stomatology; Vestibular Diseases - chemically induced; United States; Human; Peripheral vestibular syndrome; Chemotherapy; Treatment; Toxicity; Internal ear disease; Auditory disorder; ENT disease; Anticonvulsant; Phenytoin; Hearing loss

We undertook a study to identify the vestibular and hearing abnormalities associated with phenytoin toxicity. Since October 1977, 23 patients with phenytoin toxicity have been referred to the Department of Otorhinolaryngology by the Department of Neurology for electro-oculographic (EOG) evaluation....